Apoptosis is now widely recognized as a common form of cell death and represents a mechanism of cell clearance in many physiological situations where deletion of cells is required. Peptide growth factors, initially characterised as stimulators of cell proliferation, have now been shown to inhibit death in many cell types. Deprivation of growth factors leads to the induction of apoptosis, i.e. condensation of chromatin and degradation in oligonucleosomesized fragments, formation of plasma and nuclear membrane blebs and cell fragmentation into apoptotic (...) bodies which can be taken up by neighbouring cells. Here we discuss the mechanism(;s) by which growth factors may inhibit apoptosis. (shrink)

Las células madre embrionarias humanas son células pluripotentes con potenciales aplicaciones en medicina regenerativa e interés considerable en investigación y biotecnología. Sin embargo, dada la estrecha relación con principios morales y bioéticos, ha existido una considerable discusión sobre la posibilidad de patentar o no este tipo de células madre. En el presente artículo, se revisa la legislación europea en materia de propiedad industrial, y la tradición del sistema jurídico continental en el reconocimiento de la dignidad humana como principio fundamental y (...) su relación con la protección de invenciones biotecnológicas, centrados en la reciente sentencia del caso Brüstle v. Greenpeace e.V. (shrink)

BackgroundMultiple sclerosis, the most common neurological disease that causes disability in youth, does not only affect physical functions but is also associated with cognitive impairment, fatigue, depression, and anxiety and can significantly impact health-related quality of life. Since MS is generally diagnosed at a young age—a period of great significance for personal, relational, and professional development—adaptation can become highly challenging. Therefore, enhancing the competence of young people to adaptively cope with these potential challenges is of utmost importance in order to (...) promote their potentialities and talents. It has been shown that psychological interventions targeting MS patients can enhance resilience and HRQoL and that regular physical activity and social engagement can improve psychological well-being. However, literature on the development of global interventions based on the bio-psycho-social model of the disease is missing. Even less attention has been paid to interventions dedicated to young adults with MS and to the involvement of patients in the development of such programs.AimsIn collaboration with MS patients, this study aims to develop a bio-psycho-social intervention for YawMS, aiming to improve their HRQoL and to explore its feasibility, acceptability, and effects.MethodsTo tailor the intervention to the specific needs of YawMS, “patient engagement principles” will be adopted in the co-creation phase, performing a web survey and focus groups with patients and healthcare professionals. In the intervention phase, a pilot sample of 60 young adults with MS will be enrolled. The co-created intervention, composed of group sessions over a 12-week period, will cover psycho-social strategies and include physical activities. Adopting a longitudinal, pre–post evaluation design, self-report questionnaires measuring HRQoL and other bio-psycho-social features will be administered, the quantity and quality of PA will be measured, and a questionnaire developed by the authors will be used to evaluate the feasibility and acceptability of the ESPRIMO intervention. (shrink)

O presente artigo apresenta um estudo de caso sobre um serviço público que atende crianças, adolescentes e famílias vítimas de violência, abuso e exploração sexual. O objetivo foi compreender as percepções dos profissionais para esboçar uma análise das práticas sociais e relacionais da equipe para c..

Introduction: Novel coronavirus is having a devastating psychological impact on patients, especially patients with cancer. This work aims to evaluate mood disorders of cancer patients undergoing radiation therapy during COVID-19 in comparison with cancer patients who underwent radiation therapy in 2019.Materials and Methods: We included all the patients undergoing radiation therapy at our department in two-time points and during the COVID-19 outbreak. All the patients were asked to fulfill a validated questionnaire, the Symptom Distress thermometer, and the Beck Depression Inventory (...) v.2. We took into account the COVID-19 outbreak and also sex, age, week of radiation treatment, and disease.Results: We included 458 patients, with a median age of 64 years. STAI-Y1 median score was 40, whereas the median score of SDT was five and BDI-2 median score was 11. STAI-Y1, SDT, and BDI-2 were significantly correlated with the COVID-19 outbreak, sex, week of treatment, and disease.Conclusions: The prevalence of mood disorders in patients undergoing radiation therapy is higher than expected and even higher during the COVID-19 outbreak. These measurements could be useful as a baseline to start medical humanities programs to decrease these scores. (shrink)

BackgroundCo-creation allows to develop tailored interventions in chronicity and to increase patients’ engagement. Considering the interacting nature of physical, psychological, and social domains in multiple sclerosis, a biopsychosocial approach to care is crucial.AimsThis paper aims to present an example of a co-creation process in the context of chronic diseases preferences and perspectives of young adults with multiple sclerosis and healthcare professionals on the relevance, objectives, and modalities of a biopsychosocial intervention and on strategies/barriers to participation.MethodsA participatory mixed-method approach in three (...) consecutive steps was implemented: online surveys with YawMS and HCPs, online focus groups with YawMS, consultation with an advisory board composed by YawMS, HCPs and researchers. For the survey, descriptive statistics and inductive content analysis have been used for quantitative and qualitative analysis, respectively. FGs and AB were used to deepen the understanding of the survey’s results.ResultsAn integrated intervention is extremely relevant according to the perspectives of the main stakeholders. Helping disease acceptance, providing stress management strategies, and supporting emotional expression emerged as the most relevant psychological objectives according to participants. Having tangible benefits, being tailored, and fostering interpersonal relationships emerged as the main preferred characteristics of physical activity. Preferences emerged on the modalities and timing of the intervention, with a venue unrelated to the disease strongly supported. Both HCPs and YawMS highlighted as the most valuable advantages of conducting the intervention online the increased accessibility, while the main limit was the restriction to social interaction. Accessibility and lack of time resulted as the main barriers to participation.ConclusionThe co-creation process gave valuable information on preferences and perspectives of main stakeholders on objectives, modalities, and strategies to improve participation which has been used in the design of the ESPRIMO biopsychosocial intervention. Those results might inform future intervention development in the field of chronicity. The current paper outlined a co-creation methodology which might be replicated in future research on other conditions of vulnerability. (shrink)

Obstructive sleep apnea syndrome severely affects psychological well-being. This syndrome frequently occurs in obesity; however, no previous study has investigated the level of psychological well-being in the case of OSA syndrome associated with obesity. In this work, we assessed the level of psychological well-being in fifty-two individuals affected by OSA syndrome and obesity through the Psychological General Well-Being Index. Moreover, we investigated the role of personality, cognitive functioning and attentional capabilities, subjective perception and objective measurement about sleeping, on the subjective (...) perception of psychological well-being. Our sample reported a lower level of psychological well-being; the participants’ scores were below the normative cut-off in all components, except for depression symptoms. A lower expression of harm avoidance temperament and a lower level of daily sleepiness predicted a higher level of psychological well-being. Psychological well-being seemed to be severely affected in individuals affected by OSA syndrome and obesity. The temperament and subjective perception of daily alertness and sleepiness, rather than the syndrome severity, seemed to play a crucial role in the individual perception of the psychological well-being. (shrink)

Este artigo, apoiado na perspectiva teórica sócio-histórico-cultural, discute a atividade na qual sujeitos se envolvem como constitutiva dos papeis sociais que exercem. Objetiva desencadear discussão acerca da dinâmica discursiva em contextos de formação crítico-colaborativa de professores, focalizando os discursos de autoridade e internamente persuasivo (BAKHTIN, 2010) e sua coocorrência nas situações de negociação de significados. Tal distinção constitui-se relevante por permitir compreender diferentes enunciados argumentativos ou não, proferidos por educadores em formação, que se proximam ou se distanciam daqueles proferidos por (...) seus formadores ou por vozes teóricas isoladas da prática, indicando possibilidades de criação ou diminuição da expansão dialógica. A partir da ênfase no discurso internamente persuasivo, procura-se destacar o papel crítico-colaborativo da argumentação na formação de educadores. Exemplos selecionados de um corpus de pesquisa coletado em escola pública de São Paulo subsidiará a discussão, por sua vez, apoiada em Bakhtin (2010) e Vygotsky (1998; 2001). (shrink)

Partimos de unas reflexiones sobre el Racionalismo y el Historicismo como dos enfoques con perfiles epistemológicos claramente diferenciados, que llevan a quien en ellos se sitúe a muy diversos planteamientos respecto a cualquier cuestión de carácter social. Examinamos el alcance y potencial de ambos en su argumentación cuando pretenden dar cuenta del origen de la sociedad política y todo lo que ello representa, instituciones, valores… Esbozada esta cuestión se recala en el análisis jovellanista de la mujer. Jovellanos conoce bien ambos (...) enfoques, sus lecturas de los autores aquí citados están plenamente contrastadas y no son objeto de este trabajo; apuesta por el enfoque historicista inglés para comprender el rol femenino, para situar a las instituciones que le niegan su ingreso en su decurso histórico, y curiosamente convierte el modelo historicista en una vía de análisis y acceso a propuestas de una extraordinaria modernidad. Analizamos desde estos enfoques los planes de estudio en los que estamos inmersos. (shrink)

Although many of the factors that may influence donation have been identified, the timing of the interview in which families are asked for their authorisations seems to be decisive. However, there are few studies that analyse this process when the interview takes place. Qualitative techniques such as Participant Observation could help to better understand this process. One of the most recurring arguments against carrying out this type of study is the difficulty in complying with all the ethical requirements for any (...) research as defined in biomedical research guidelines and committees. This article aims to contribute to a discussion on the ethical viability of conducting an in situ study on family interviewing and proposes a strategy for minimising possible risks in designing a study of these characteristics. (shrink)

En este artículo se analiza la importancia del trabajo textil realizado por las mujeres en la Grecia antigua. Se presentarán algunos pasajes homéricos para guiar el reconocimiento del concepto de unas manos pensantes en el que una actividad teórico-práctica es capaz de transmitir poderosos mensajes no hablados desde la vulnerabilidad de lo femenino que, al contrario de lo que tradicionalmente podría pensarse, tienen una dimensión política. Para ello se procederá en tres apartados. En el primero, se indicará el modo en (...) que el trabajo manual puede ser comprendido como ejercicio intelectual en el mundo griego; en el segundo, se revisará cómo el tejido se entiende desde lo humano y la manera en la que Atenea es símbolo de la textilidad que reviste a lo humano, y en el tercero se afirma que la práctica del tejido es una forma idónea de reivindicación de la figura femenina. Finalmente, la conclusión muestra cómo esta práctica sigue vigente hoy. (shrink)

Environmental virtues have become an essential ingredient in an ethics of nature. An account of environmental virtues can contribute to this ethics of natre by exploring the virtues that the gardener displays in cultivating and caring for plants. An approach that relates to the virtues of gardening is helpful in explicating a more general approach in a certain domain of interaction with nature. Good gardeners get involved in processes of natural growth and decay, they are aware of their position within (...) the garden, and they endure ambivalences in nature. This relational account of the virtues of gardening is also exemplary in processes of active co-designing of nature and in landscaping. (shrink)

Chez Aristophane, le public est impliqué dans le jeu comique, grâce à la disposition physique de l’espace théâtral. Il est raisonnable de penser que les femmes faisaient partie du public. Ce travail analyse les vv. 42 ss. de Lysistrata, où il semble que Cléonice s’adresse aux femmes assises dans la cavea.

Riassunto : Il fenomeno delle “near-death experiences”, esperienze soggettive intense e profonde, è caratterizzato dalla percezione di essere in una dimensione diversa da quella ordinaria, di aver abbandonato il proprio corpo e, con esso, la dimensione spazio-temporale del mondo fisico. Il termine NDE è utilizzato per indicare esperienze simili occorse in condizioni cliniche molto diverse, ad esempio l’arresto cardiaco, il coma, lo svenimento o l’assunzione di sostanze psicotrope. In questo lavoro si considerano esclusivamente quelle esperienze sperimentate in condizioni di prossimità (...) alla morte. Il fenomeno viene discusso confrontando gli elementi più comunemente presenti nelle NDE di soggetti occidentali con quelli riportati da soggetti di altre culture. Le varie esperienze pre-morte sono discusse in funzione dei contenuti riportati e delle modalità con cui si sono verificate. Infine, lo stato di coma è stato valutato come condizione di “near-death” nell’ottica di considerare la morte come un processo. Parole chiave: Near-death Experiences; Cultura; Coscienza; Memoria; Arresto cardiaco; Coma Towards a definition of “near-death experiences”: Physiologic, psychologic and cultural dimensions: The phenomenon of near-death experiences, intense and profound subjective experiences, is characterized by the perception of being in a different dimension from the ordinary one, of having abandoned one’s body and, with it, the space-time dimension of the physical world. The term NDE has been used to indicate similar experiences that occurred in very different clinical conditions, namely cardiac arrest, coma, fainting, use of psychotropic substances, etc. In what follows will be considered only experiences taking place in conditions of proximity to death. The phenomenon will be discussed comparing elements most commonly present in NDEs of Western subjects with those reported by subjects from other cultures. The various near-death experiences will be discussed in according to the contents reported and the ways in which they occurred. Finally, the state of coma was considered as a near-death condition under the assumption of death as a process. Keywords: Near-Death Experiences; Culture; Consciousness; Memory; Cardiac Arrest; Coma. (shrink)

Large parts of our world are filled with plants, and human life depends on, interacts with, affects and is affected by plant life in various ways. Yet plants have not received nearly as much attention from philosophers and ethicists as they deserve. In environmental philosophy, plants are often swiftly subsumed under the categories of "all living things" and rarely considered thematically. There is a need for developing a more sophisticated theoretical understanding of plants and their practical role in human experience. (...) Plant Ethics: Concepts and Applications aims at opening a philosophical discussion that may begin to fill that gap. The book investigates issues in plants ontology, ethics and the role of plants and their cultivation in various fields of application. It explores and develops important concepts to shape and frame plants-related philosophical questions accurately, including new ideas of how to address moral questions when confronted with plants in concrete scenarios. This edited volume brings together for the first time, and in an interdisciplinary spirit, contemporary approaches to plant ethics by international scholars of established reputation. It will be of great interest to students and scholars of Philosophy and Ethics. (shrink)

Normal 0 21 false false false PT-BR X-NONE X-NONE MicrosoftInternetExplorer4 Normal 0 21 false false false PT-BR X-NONE X-NONE MicrosoftInternetExplorer4 Normative fragment of natural language make up sentences that express acts and describe norms. In this fragment there are criteria of logic thuth and relation of consequence between sentences which constitute a natural deontic logic. This paper adopts at ranslation function from the set of sentences of the normative fragment of natural language in to the set of formulae in the (...) formal language and claims that such function translates logically true sentences of the natural language into provable formulae of the formal calculus. With Von Wright's deontic calculus (1951), it does not fit and generates paradoxes, which are known as Prior's paradoxes. Cruz's paraconsistent deontic propositional calculus, D 1 (1993) avoids some paradoxes, except that generated by the formula OB-O (A- B). One builds a relevant deontic propositional calculus that aims to avoid these paradoxes and keeps intact all other fundamental features of deontic operators, since the formula B - (A - B) is improable in some relavant calculi.  . (shrink)

Este artigo objetivou investigar a síndrome de burnout em estudantes de um curso técnico de enfermagem. Procurou identificar também a existência de associação entre variáveis demográficas e escolares e fatores de estresse numa amostra de 255 estudantes. Como instrumentos de pesquisa foi utilizado um..

This essay introduces a special collection of papers by Angela Creager, Soraya de Chadarevian, Karen Rader, Jean-Paul Gaudillière, and María Jesús Santesmases on the theme "Radiobiology in the Atomic Age.".

The upbringing of infants in native communities is the concern of authorities and researchers for being a vulnerable population segment. The purpose of the study was to analyze child rearing styles of an Amuesha community in the Peruvian jungle. The phenomenological design allowed interviewing amuesha mothers from Oxapampa in Pasco, until reaching saturation. It was found as results that child rearing practices conform to sociocultural patterns, such as identity and communal heritage culture, which are in extinction due to the presence (...) of exotic factors; in addition to a demand to the State for better education and health services. (shrink)

O presente trabalho é decorrente do Projeto de Pesquisa Intervenção “Phenix – a ousadia do renascimento do indivíduo-sujeito – fase IV”, vinculado a Universidade Estadual de Maringá. As teorizações aqui realizadas partiram de encontros realizados entre graduandos e pós-graduandos de psicologia com adolescentes pauperizados de uma escola pública localizada na periferia de Maringá-PR, cujo foco foi propiciar uma reflexão crítica acerca do cotidiano desses adolescentes a partir de Psicanálise e de pressupostos da Teoria Crítica de Adorno. A princípio serão apresentadas (...) nesse trabalho algumas considerações sobre os processos de identificação, adesão e reprodução de discursos totalizantes relacionados a ideias meritocráticas e patriarcalistas que foram discutidas com os adolescentes, com o intuito de desmistificar alguns modelos pré-formatados de família, de homem e de mulher impostos na sociedade contemporânea. Na sequência, serão realizadas breves considerações sobre as especificidades do adolescer dentro de um contexto pauperizado e significativamente marcado pelos imperativos do consumo, via indústria cultural. (shrink)

RESUMO Este artigo analisa a peça Mãe, de José de Alencar, que tem por cenário o Rio de Janeiro da segunda metade do séc. XIX, retratando a escravidão africana doméstica. Fundamenta-se nas ideias de Bakhtin e do Círculo, focalizando as vozes sociais sobre a escravidão presentes nas falas das personagens. A investigação leva o leitor a perceber os posicionamentos sobre a escravidão presentes no cotidiano nacional que migram para o interior do drama alencariano. Também se mobilizaram discursos historiográficos do século (...) XX que estabelecem dialogia com a obra alencariana. As falas retratam as personagens ora submetidas ao regime escravista, ora em situação autonômica, representando a resistência ao cativeiro. A leitura da peça é importante para as gerações atuais, visto que a cultura escravocrata perdura em nossa sociedade. ABSTRACT This paper analyzes the drama Mãe, written by Jose de Alencar. The narrative takes place in Rio de Janeiro in the second half of nineteenth-century and portrays domestic African slavery. The theoretical background is based on the ideas of Bakhtin and the Circle, focusing on the social discourses about slavery in Brazilian society present in the characters’ speeches. This investigation leads readers to perceive the positions on slavery that society supported and that penetrate Mãe. Some historical discourses written in the twentieth century are analyzed, offering a dialogical dimension to Alencar’s play. The characters’ voices portray either their submission to slavery or their autonomy, the latter representing their resistance to captivity. Reading this drama today is important because of the slave culture that still prevails in our society. (shrink)

Entrevista realizada en Buenos Aires el 22 de noviembre de 2018, a María Herrera Magdaleno, madre de personas desaparecidas en México y activista por los derechos humanos, donde presenta las luchas del movimiento de familiares de desaparecidos en México y las labores llevadas adelante por la Cuarta Brigada Nacional de Búsqueda de Personas.